人工授精后早孕相关因子检测及在早孕诊断中的应用价值

Detection and Applicable Value of Early Pregnancy Associated Factor in Diagnosis of Early Pregnan- cy.

通过检测妇女行人工授精术(AID)后血小板计数(PLT)、预植入因子(PIF)、白细胞介素1(IL-1β)的变化,探讨三种早孕相关因子在超早孕诊断中的应用价值。结果显示,授精后48小时,化学妊娠组和未妊娠血小板下降组PLT明显下降,PIF明显升高,与对照组和血小板上升组相比差异显著(P<0.001)。IL-1β升高但差异不显著。未妊娠血小板下降组与化学妊娠组具相同的变化趋势,前者很可能是卵受精而未植入。通过受精后PLT下降,PIF升高,可简单、快速判定体内是否有受精卵。

The variability of platelet count (PLT) ,pre-implantation factor (PIF) ,Interleukin-1β(IL-1β)in women performing artificial insemination donor (AID) was detected to explore the applicable value of these three kinds of early pregnancy associated factor in diagnosis of early pregnancy. Results : Compared with control group and non-pregnant group with the increase of platelet, PLT was significantly decreased and PIF increased (P<0. 001) in chemical pregnant group and non-pregnant group with the decrease of platelet 48hr after fertilization.and IL-1β increased but not significantly. These suggest that non-pregnant group with the decrease of platelet and chemical pregnant group have the same trend of variability. The former may have fertilized ovum which not be implanted successfully. The decrease of PLT and increase of PIF after fertilization can simply quickly determine fertilized ovum in the body.