类风湿关节炎间质性肺疾病与临床免疫学指标的关系

Relationship between clinic and index of commune and interstitial lung involvement inpatients with rheumatic arthritis

目的 探讨类风湿关节炎（ＲＡ）患者间质性肺疾病与临床及类风湿因子（ＲＦ）、血沉（ＥＳＲ）、Ｃ反应蛋白（ＣＲＰ）补体、免疫复合物及免疫球蛋白的关系。方法 类风湿关节炎患者１０２例分成两组，一组是伴有间质性肺病变２５例，另一组是不伴有间质性肺病变７７例。所有患者均测定类风湿因子、血沉、Ｃ反应蛋白、补体、免疫复合物、免疫球蛋白。结果类风湿关节炎发生间质性肺疾病的发生率为２４．５％，男性多见。类风湿关节炎发生间质性肺疾病组的病程、类风湿因子滴定度、血沉、Ｃ反应蛋白、免疫复合物均明显高于无间质性肺疾病组（Ｐ＜０．０５），补体３、４低于无间质性肺疾病组（Ｐ＜０．０５），两组的年龄、免疫球蛋白无统计学差异（Ｐ＞０．０５）。结论 高滴度类风湿因子、免疫复合物、低补体提示间质性肺疾病的可能，类风湿关节炎患者应注意早期治疗，控制疾病活动度。

Objective To investigate the relationship between clinic,RF titer,ESR,CRP,C3,C4,CiC,IgA,IgG,IgM and interstitial lung involvement in Patients with rheumatic arthritis(RA). Methods 102 Patients with rheumatic arthritis was divided into two groups,25 patients with interstitial lung involvement,77 patients with no interstitial lung involvement. We tested RF titer,ESR,CRP,C3,C4,CiC,IgA,IgG,IgM.Results The incidence of RA with interstitial lung involvement was 24.5%. The disease in male was higher than in female. An extension,RF titer,ESR,CRP,CiC in patients with the intersitital lung involvement of RA were significantly higher than those in patients with no interstitial lung involvement of RA(P＜0.05) ,C3,C4 was lower (P＜0.05) . C3,C4 was lower(P＜0.05) Age and IgA IgG IgM of two groups were not different(P＞0.05). Conclusion The rising of RF titer and immune complex,the low of C3,C4 in patients suggest interstitial lung involvement,These patients with RA were treated and controled early.