“夹心面包”法肝动脉化疗栓塞治疗原发性肝癌的临床研究(附120例分析)

HEPATIC ARTERIAL INFUSION CHEMOTHERAPY AND EMBOLIZATION LIKE "SANDWICH" FOR TREATMENT OF PRIMARY HEPATIC CARCINOMA— AN ANALYSIS OF 120 CASES

目的 :评价“夹心面包”法治疗原发性肝癌的临床应用价值。方法 :回顾性分析 1 2 0例经“夹心面包”法治疗原发性肝癌的临床随访资料。结果 :本组病例 1、2、3年累计生存率分别为 81 .7% ,65 .0 % ,41 .8% ,平均生存期 2 8.3个月 ,最长已存活 62个月 ,获二期手术切除 1 6例 ,肿瘤缩小者占 78.3 % ,AFP下降者占76.7%。结论 :“夹心面包”法治疗原发性肝癌使肿瘤内药物存留时间长、浓度高 ,能提高疗效 。

Objective:To evaluate the clinical value of hepatic arterial infusion chemotherapy and embolization like 'sandwich' in the treatment of primary hepatic carcinoma.Methods:Follow up data of 120 patients with primary hepatic carcinoma treated by hepatic arterial infusion chemotherapy and embolization like 'sandwich' were analysed retrospectively.Results:The 1 ,2 ,and 3 year survival rates were 81 7%,65 0%,and 40 8% respectively,with mean survival time being 28 3 months and the longest survival period 62 months.Sixteen patients gained chance for the second surgical resection.There was a shrunk tumor in 78.3% of the patients and a decreased AFP in 76 7%.Conclusion:The method for treatment of primary hepatic carcinoma might increase concentrations of drugs in the tumor,lengthen the time of action,and improve therapeutic effects.