摘要
目的 :研究椎基底动脉供血不足 (VBI)所致的眩晕、共济失调、耳鸣、无力等 ,用西比灵治疗前后血液流变性、经颅多普勒 (TCD)及甲襞微循环的变化和症状改善情况。方法 :76例VBI患者随机分为二组 ,以维脑路通作对照 ,常规用药 ,治疗前后检查上述指标。结果 :西比灵治疗后血浆粘度、红细胞压积和红细胞聚集指数显著下降 ,TCD检查血流速度加快 ,频谱频窗异常状况有明显好转 ,甲襞微循环流速流态、管袢清晰度及临床症状显著改善 (P <0 .0 5～ 0 .0 1 )。结论 :西比灵能扩张血管 ,降低血粘度 ,改善微循环 ,治疗VBI。
To study effects of sibelium in the treatment of dizz iness and vertigo caused by vertebrobasilar insufficiency(VBI),to observe change s of hemorheology,Transocranial Doppler(TCD) and nailfold microcirculation in be fore and after treatment with sibelium.Method: 76 patients with VBI were randomly divided into 2 groups :sibelium treatment and Wei nao lu tong treatment group,38 patients were given s ibelium 5～10 mg every evening,a treatment course was 5 weeks,Wei nao lu tong was used as controls.In before and after treatment,aboved idems were checked u p.Results: Sibelium obviously reduced blood viscosity,erythrocyte eggregation,hematocrit and improve TCD,nailfold microcirculation and clinical sy mptoms.Conclusion: Sibelium is a class IV calcium antagonist,it may dil ate blood vessel,reduce blood viscosity,improve microcirculation and cerebral bl ood supply,protect cerebrocells.Therefore,sibelium is ideal drug to treatment V BI and pevent ischemic cerebrovascular diseases.
出处
《微循环学杂志》
2002年第1期16-17,共2页
Chinese Journal of Microcirculation
关键词
西比灵
治疗
椎基底动脉供血不足
Sibelium
Vertebrobasilar insufficiency
Hemorheology TCD
Nailfold microcirculation
