高原藏汉成人接种乙肝疫苗后机体的免疫应答

The immune response of hepatitis B vaccine on the native tibetan and migrated Hans at high altitude

目的 :了解高原低氧环境下接种乙肝疫苗后机体的免疫应答。方法 :采用 0— 1— 6月的免疫程序 ,每次注射重组酵母乙肝疫苗 5 μg 0 5ml,接种藏汉成人“乙肝易感者”2 4 3例 ,并进行了 3年的随访观察。结果 :不同性别、不同民族间HBsAb阳转率差异无显著性 (x2 值分别为 0 0 19和 0 0 4 4 ,P >0 0 5 ) ,第 1— 3年总保护率分别为 95 9%、95 5 %和92 2 %,第三年开始下降 ,较第 1年降低 3 9%,差异无显著性 (x2 =1 37,P >0 0 5 )。结论 :提示在高原低氧环境下成人“乙肝易感者”接种乙肝疫苗后机体的免疫应答良好 ,对降低西藏地区乙型肝炎病毒的慢性携带率和乙肝的发病率均具有重要的意义。

Objective:To study the immune response of hepatitis B vaccine at high altitude.Methods:'Hepatitis B sensitive subjects'from 123 native tibetins and 120 migrated Hans received hepatitis B vaccines(T 0,T 1,T 6-month,5μg/ml),and was follow-up researched for 3 years.Result:The anti-HBs positive rates was not different between the native tibetan group and the migrated Hans group,also between the male group and the female group(x 2=0.019 and 0.044,P>0.05).The anti-HBs positive rates decreased from 95.9% to 92.2%(x 2=1.37,P>0.05).Conclusion:After hepatitis B sensitive persons among native tibetan and migrated Hans received hepatitis B vaccine,the immune response of the vaccine was good.Hepatitis B vaccination could reduce remarkably the infectious rate of HBV and the prevalence rate of HBV at high altitude.