大蒜素、沙棘油、银杏叶提取物对顺铂所致大鼠肾损害预防作用的初步研究

Primary study of the preventive effects of allicin, Hippohae rhamnoides oil and ginkgo bible extract on cisplatin-induced nephrotoxicity

目的 :研究大蒜素、沙棘油、银杏叶提取物对顺铂(CDDP)所致肾损害的预防作用。方法 :将 3 0只SD大鼠随机分 5组 ,分别为对照组(生理盐水组)、CDDP组、CDDP +银杏叶提取物组、CDDP +大蒜素组、CDDP +沙棘油组 ,进行急性毒性实验 ,分别测定体重、肾脏系数、血清尿素氮等指标(BUN)。结果 :CDDP+大蒜素组和CDDP +沙棘油组BUN水平较CDDP组明显降低 (P <0 .0 5 )。结论

Objective: To study the preventive effects of allicin, Hippohae rhamnoides oil and ginkgo bible extract (GBE) on cisplatin(CDDP)-induced nephrotoxicity. Methods: SD rats were randomly divided into five groups, respectively as follows: Control (NS), Group CDDP, Group CDDP+GBE, Group CDDP+allicin, Group CDDP+ Hippohae. The studies of the acute toxicity studies were carried out. Body weight, renal index and blood urea nitrogen (BUN) were assayed. Results: BUN of Group CDDP+allicin and Group CDDP+ Hippohae were significantly less than that of Group CDDP (P<0.05). Conclusions: Allicin and Hippohae rhamnoides oil could reduce CDDP-induced nephrotoxicity.