EVA膜对青蒿琥酯经皮渗透影响的研究

A study on the Transdermal Penetration of Artesunate from various EVA Membranes

目的 对影响EVA膜控释性能的条件进行考察 ,确定最佳制备工艺并探讨其对青蒿琥酯经皮渗透的影响。方法 采用正交设计试验法 ,以透皮吸收速率常数为考察指标 ,对EVA2 8、EVA36不同浓度溶液以不同工艺制备的控释膜进行经皮渗透实验。结果 应用EVA36 ,氯仿溶解成 10 %浓度溶液 ,不加增塑剂 ,薄膜涂布器 0 5 μm铺膜 ,80℃干燥 6h。回归各实验Q -t方程 ,确定为最佳制备工艺。

With transdermal absorption speed constant as index, the percutaneous osmosis experiments were carried out by orthodox design method to study the preparation process of EVA membrane.The results indicate that the best preparation process of EVA membrane is:10% EVA 36,dissolved by chloroform without the addition of plasticizer, expanding the membrane at the thickness of 0 5 μm, dried at 80℃ for 6 hours. The membrane is with good releasing-control activity under the above condition.