碱性成纤维细胞生长因子(bFGF)相关结合蛋白

Binding proteins of basic fibroblast growth factors

有四种不同类型的细胞表面或细胞外基质中的蛋白质分子在结合碱性成纤维细胞生长因子 (bFGF)、辅助其发挥生物功能活性方面起着重要的作用。它们是 :(1)细胞膜上的具有酪氨酸激酶活性的FGF受体家族 (FGFRs) ;(2 )细胞外基质中的硫酸乙酰肝素蛋白多糖家族 (HSPGs) ;(3)细胞内富含半胱氨酸的FGF受体 (CFR) ;(4)分泌型的FGF结合蛋白 (FGF BP)。

Four distinct types molecule in cell surface or extracellular interact with basic fibroblast growth factors(bFGF)that can regulate bFGF signaling and biological activity. They are: (ⅰ)FGF receptor tyrosine kinases (through FGFR\|1 to FGFR\|4); (ⅱ)heparan sulfate proteoglycan (HSPG); (ⅲ)a cysteine\|rich FGF receptor (CFR); (ⅳ)a secretive FGF\|binding protein(FGF\|BP);In this article,we try to introduce their functions that involved in the bio\|activity of FGFs.\;