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脂多糖激活靶细胞NF-κB的机制与途径的研究进展 被引量:2

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摘要 真核细胞核转录因子Rel/NF-κB是近年来发现的一类具有多向性转录调控作用的蛋白质因子,广泛调控着自昆虫至人类的免疫和炎症反应中一系列基因的表达。静息时,Rel/NF-κB二聚体与其抑制蛋白IκB结合成三聚体存在于胞质中,胞外刺激通过不同的信号转导途径使IκB降解,活化的NF-κB进入核内发挥功能。本文本要介绍了脂多糖激活靶细胞NF-κB的分子机制及酪氨酸蛋白激酶、丝裂原激活的蛋白激酶、蛋白激酶C等相关胞内信号转导途径的研究进展。
作者 黎庶 汪正清
出处 《国外医学(微生物学分册)》 2002年第1期20-22,30,共4页
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同被引文献23

  • 1邱海波,潘家绮,赵永强,杜斌,陈德昌.内毒素诱导器官损伤中炎症性细胞因子的表达及药物治疗探讨[J].中华医学杂志,1996,76(4):254-257. 被引量:25
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