杆状病毒细胞凋亡抑制基因的研究进展

Recent advances in baculoviral inhibitor of apoptosis

细胞凋亡是多细胞生物为维持自身的正常机能而产生的细胞自杀性行为 ,杆状病毒为维持自身的生长繁殖而产生了对抗细胞凋亡的基因 p35和 iap,二者分别作用于细胞凋亡途径的不同部位 ,以抑制细胞的凋亡 .近年来人们对这两种基因的蛋白结构及作用机制等方面进行了大量的研究 ,对它们的作用机制有了进一步的了解 。

WT5”BZ]Apoptosis is an active process of cellular self destruction that is involved in normal development. Two kinds of anti apoptosis genes p 35 and iap have been identified in baculovirus genome. Both of them function at different point in the death pathway. Extensive studies have been made about the structures and function mechanisms of the genes and their products. This review highlights the recent advances in the researches of the genes and their function mechanisms and explores the possible utilizations in the future. [WT5”HZ]