卵巢癌p53蛋白表达与细胞增殖状态及预后的关系

Expression of p53 Protein in Ovarian Cancer and Its Relationship to CellProliferative Activity and Prognosis

目的 探讨p5 3蛋白的表达与细胞增殖状态及预后的关系 ,并评价其临床应用价值。方法 应用S P免疫组化法 ,研究 6 8例卵巢癌p5 3蛋白的表达及其与细胞增殖活性、淋巴结转移及生存期的关系。结果 5 2 .9%卵巢癌组织中存在p5 3蛋白的异常表达。p5 3蛋白阳性的卵巢癌其细胞增殖活性较阴性者高 (P <0 .0 5 )。其生存期也较阴性者明显缩短 (P <0 .0 5 ) ,但与淋巴结转移无关 (P >0 .0 5 )。结论 p5 3基因的突变以及由此导致的细胞异常增殖与卵巢癌的发生有关 ,与淋巴结转移无关。检测p5 3蛋白表达对判断肿瘤的恶性程度及预测预后有重要参考价值。

Objective To reaserch the relationship of expression of p53 protein in ovarian cancer and its relationship to cell proliferative and prognosis.Methods The expression of p53 protein in 68 cases of ovarian cancer and its relationship to cell proliferative activity,lymph node metastasis as well as prognosis were investigated by means of S-P immunohistochemical technique.Results 52.9% of ovarian cancer was positive.The cell proliferative activity in p53-positive cases was significantly higher than that of p53-negative tumors (P<0.05).The survival in patients with p53-positive tumors was significantly shorter than those with p53 negative tumors (P<0.05).Conclusions The abnormal expression of p53 and cell proliferating associated with mutation are involved in human carcinogenesis.Examination of p53 expression is of great value in understanding the degree of malignancy,and evaluating prognosis of the disease.;