新生儿败血症的菌群分布及耐药性分析

Neonatal Ichorrhemia:Distribution of Bacteria Group and Drug Resistance

目的 了解病原菌在新生儿败血症中的菌群分布及耐药性 ,指导临床合理用药。方法 对 5 2 3株从新生儿败血症血培养中分离的阳性菌进行回顾性分析。结果 分离的 5 2 3株病原菌中占首位的是葡萄球菌(81.9%) ,其中凝固酶阴性葡萄球菌 (CNS)占 5 3.7%;其次是革兰阴性杆菌 (7.5 %) ,13株大肠埃希菌和 9株肺炎克雷伯菌中ESBLs 13.6 %(3/ 2 2 )。药物敏感试验显示病原菌对氨基糖苷类药物中的阿米卡星及第三代头孢菌素中的头孢哌酮、头孢噻肟有较高的敏感率。结论 新生儿败血症病情发展快 ,临床症状无特异性 ,须引起高度重视 ,并积极抽送血培养以快速确诊及指导合理用药 ;在未获得明确病原菌之前 ,可早期选用阿米卡星、头孢哌酮和头孢噻肟 ,以提高疗效。

Objective To explore the distribution, group resistance of pathogenic bacteria of neonatal ichorrhemia,and the aim is to help doctors use antibiotics rationally.Methods We took retrospective analyses in 523 strains of pathogenic bacteria which isolated from patients with neonatal ichorrhemia.Results Among 523 strains of pathogenic bacteria,the staphylococcus accounted for the largest part (81.1%),among those coagulase-negative staphylococci accounted for 53.7%, the second was G-bacilus(7.5%).Furthermore,we detected 13 strains E.coli and 9 strains klebsiella produced extended-spectrum β-lactamases (ESBLs).On the other side,all of the pathogenic bacteria showed higher sensitivity to amikacin,cefoperazone,cefotaxime.Conclusions Neonatal ichorrhemia had no clinical specific symptom and its development was very fast,so we should attach importance to it,and take blood culture in time for rational use of medicines.Our data indicated that before the pathogenic organism had been ascertained, clinicians could choose amikacin,cefoperazone,cefotaxime to treat the case of neonatal ichorrhemia,and promote therapeutic effects.;