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大黄乙醇提取物的体外抗新城疫病毒作用 被引量:9

Anti viral effect of rhubarb ethanol extract on Newcastle disease virus
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摘要 目的:研究大黄乙醇提取物的抗新城疫病毒(NDV)作用。方法:采用体外细胞培养的方法研究大黄乙醇提取物对NDV感染的拮抗作用。结果:20g/L剂量大黄乙醇提取物对BHK21细胞未有任何毒性作用;0.5g/L大黄对NDV所致CPE有明显的抑制作用;大黄可预防NDV感染,并对NDV的复制动力学有明显影响。结论:大黄乙醇提取物具有明显的抗NDV作用。 Objective:To study the anti viral effect of rhub arb ethanol extract on Newcastle disease virus(NDV) in vitro.Methods:Cell culture was utilized to investi gate the anti NDV effect of rhubarb ethanol extract, including its cytoto xity, inhibition of cytopathic effect, prevention of NDV infection and the effe ct on dynamics of viral replication.Results:The extract demonstrated very low cytotoxicity, there being no cytotoxicity at all at the concent ration of 20g/L. Its inhibition effect on CPE caused by NDV was obvious at the dose of 0.5g/L, but weaker than on HSV 1. However, its direct effect on virus particles was stronger than on HSV 1.The extract could also pr e vent NDV infection and had marked effect on dynamics of replication.Conclu sion: Rhubarb eth anol extract can obviously inhibit NDV infection and has broad spectrum anti v iral effect. Therefore, rhubarb is an ideal a ntiviral drug with a very good clinical prospects.
出处 《山东医科大学学报》 2002年第1期26-28,共3页 Acta Academiae Medicinae Shandong
基金 山东省卫生厅资助课题
关键词 大黄 新城疫病毒 体外研究 乙醇提取物 细胞培养 WORDS Rhubarb Newcastle disease virus Cells, cultured In vitro
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