普罗布考抑制冠脉成形术后血管内膜增生的实验研究

Effects of probucol on neointimal hyperplasia after coronary angioplasty in a swine model

目的：建立猪冠状动脉球囊损伤模型，观察普罗布考对损伤动脉内膜增生的影响。方法：选用雌性大约克夏猪１９只，随机分为对照组１１只，普罗布考组８只，于术前４ｗ给予普罗布考，两组均行冠状动脉球囊扩张术，术后喂饲６ｗ，重复冠脉造影后处死。选取损伤的冠状动脉，常规病理制片，观察形态学变化，并计算损伤动脉的内膜面积占有率。结果：对照组损伤动脉内膜可见大量平滑肌细胞增生，呈偏心性增厚，使管腔狭窄，内膜面积占有率为５６．０１％〔（５６．０１±１７．８５）％〕，普罗布考组损伤动脉内膜面积占有率为３０．２７％〔（３０．２７±２０．９７）％〕，内膜增厚程度较对照组明显减低（Ｐ＜０．０５）。结论：普罗布考具有抑制冠脉成形术后损伤血管内膜增生的作用。

Objective:To observe the effect of probucol on ne ointimal hyperplasia after coronary angioplasty in a swine model.Methods :Nineteen female New Yorkshire pigs were randomly assigned to receive 2g/d of probucol or control therapy for 4 weeks before percutaneous transluminal coronary angioplasty(PTCA) , th en PTCA was performed on all the pigs,and probucol was continued until follow up an giography for 6 weeks after PTCA. Then the animals were killed, the injured coro nary arteries were dissected and examined histopathologic ally. The intima a rea ratio was measured.Results:The injured arteries in the control grou p revealed marked eccentric neointima formation with cell proliferation of vascu lar smooth muscle.The intima area ratio was 56.01%.A smaller intima area ratio was observed in the prob ucol group(69.87%) compared with the control group with statistical significance (P<0.05).Conclusion:Probucol can decrease the neoint imal hyperplasia after PTCA.