降纤酶对急性脑梗死患者血液学变化的影响

Effects of defibrase on hematological change in patients with acute cerebral infarction

目的：研究降纤酶对急性脑梗死患者血液流变学、血凝学及Ｄ二聚体的影响，以及对脑梗死治疗的作用机制。方法：抽取急性脑梗死患者的静脉血，测定用降纤酶治疗前后的血液流变学、血凝学与Ｄ二聚体的变化。结果：降纤酶治疗前后血液流变学５项指标、血凝学２项指标ＣＴ和ＰＰＴ、Ｄ二聚体比较差异均有统计学意义；降纤酶组与常规治疗组的全血粘度、Ｄ二聚体差异有统计学意义，Ｐ＜０．０５，血浆粘度、纤维蛋白原比较差异有统计学意义，Ｐ＜０．００１，血凝学３项指标差异无统计学意义，Ｐ＞０．０５。结论：降纤酶可降低急性脑梗死患者的血粘度，尤其是纤维蛋白原、ＨＣＴ，并使Ｄ二聚体升高，但不增加出血倾向，是治疗急性脑梗死的有效药物。

Objective:To investigate the changes of hemorheol ogy,hemoaggltination a nd D-dimer in patients with acute cerebral infarction treated with defibra se and the mechanism of defibrase in the treatment of acute cerebral infarcti on.Methods:The changes of hemorheology ,hemoaggltinat ion and D-dimer were determined before and after treatment with defibrase in 86 cases of acute cerebral infarction.Results:(1) In defibrase groups, th ere change were significant in hemorheology ,hemoagg ltination and D-dimer. (2) Compared with contrast group,there were significant differences,in the changes of h emorheology and D-dimer ,but no statistical differences in three indexes of hemoaggltination.Concl usion:Defibrase can dec rease blood viscos ity ，especially fibrinogen and HCT，in acute cerebral infarction,and it can al so increase D-dimer,but does not show hemorrhagic tendency,therefore defib rase was an effective drug in the treatment of acute cerebral infarction.