产超广谱β-内酰胺酶细菌的种类及耐药特性

Types and drug resistance of extended-spectrum beta-lactamase producing bacteria

目的：研究质粒介导的超广谱β内酰胺酶（ＥＳＢＬ）细菌的种类和耐药特性。方法：采用Ｅｔｅｓｔ法对可疑细菌行ＥＳＢＬ检测，用ＫＢ法做药物敏感试验，用ＷＨＯＮＥＴ４软件进行分析。结果：在８９０株革兰阴性杆菌中检出产ＥＳＢＬ菌４４株， 阳性率４．９％。对亚胺培南、呋喃妥因、阿米卡星、环丙沙星的敏感率分别为１００％、６８．２％、２９．５％、２５．０％。结论：产ＥＳＢＬ细菌分布广泛、阳性率高，易借助耐药质粒传播，具有较高的交叉耐药性和多重耐药性。

Objective:To study the types and drug resistance of plasmid transferred exte nded spectrum beta lactamase (ESBL) producing bacteria.Methods:Etest was adopted to detect the suspicious ESBL isolates. Microbial sensitivi ty tests were carried out with K B ,and the results were analysed with WHONE4 software.Results:From 890 strains of Gram negative bacilli, 44 ESBL producing strains were detected with a positive rate of 4.9%. The sensitive rates of ESBL to imipenem, nitrofur antion, amikacin, ciprofloxacin were 100%,68.2%,29.5% and 25.0% respective ly.Conclusion:The ESBL producing bactera distribute broadly,are easy to detect and spread easily through resistant plasmid with high cross resistance and multi resistance