丹参/三七不同配比药效学比较研究——对急性实验性心肌缺血犬心肌生化标志物的影响

Comparative Research on Pharmacodynamics of Different Matching of Danshen and Sanqi-Effect on Myocardial Biochemical Indices of Dog with Experimental Acute Myocardial Ischemia(AMI)

目的 :观察丹参/三七的7种配比对心肌生化标志物的影响。方法 :采用经典模型———冠脉前降支结扎法 ,经十二指肠给药 ,测量实验起止点的心肌钙蛋白 (cTnI)和肌酸激酶同工酶 (CK -MB)。结果 :两种生化标志物反映的结果并不一致 ,7种配比中10/0、10/1、10/3、10/6、10/10均能使cTnI降低 (P<0.05 ,P<0.01) ;10/0、10/1、10/3、10/6、1/10、0/10可使CK -MB降低 (P<0.05)。结论

Objective: To observe the effect of 7 different proportions of Danshen Root and Sanqi on myocardial biochemical indiced in dogs with AMI.Methods: AMI model was produced in dog by coronary artery ligation. CTnI and CK-MB concentrations were measured after duodenal administration of drugs. Results: cTnI could be reduced at the proportion of 10/0,10/1,10/3, 10/6,10/10(P<0.05,P<0.01), while CK-MB lowered at the proportion of 10/0,10/1,10/3,10/6.1/10,0/10(P<0.05). Conclusion: The direct effect of Danshen Root on cardiovascular function was better than Sanqi.