蛇床子素对AlCl_3致急性衰老模型小鼠记忆障碍的保护作用

EFFECT OF OSTHOL ON MEMORY IMPAIRMENT OF MICE IN AlCl_3-INDUCED ACUTE SENILE MODEL

目的 研究蛇床子素对AlCl3 致急性衰老模型小鼠记忆障碍的保护作用及其机制。方法 通过小鼠避暗实验和跳台实验、血浆和脑组织超氧物歧化酶 (SOD)活性及全血谷胱甘肽过氧化物酶 (GSH PX)活性测定 ,观察蛇床子素对AlCl3 造成小鼠记忆障碍模型的保护作用。结果 蛇床子素能明显改善AlCl3 所致被动回避性记忆障碍 ,增强SOD和GSH PX活性。结论 蛇床子素对AlCl3 致急性衰老模型小鼠记忆障碍有保护作用 ,其作用机制可能是通过增强抗氧化酶GSH PX和SOD活性来清除氧自由基对中枢神经系统神经细胞的损伤。

AIM To study the protective effect and mechanism of osthol on learning and memory impairment of mice with acute senile model induced by AlCl 3. METHODS After sc AlCl 3 60 mg·kg -1 for 7 d and ip osthol 15 and 7 5 mg·kg -1 for 12 d, using step-through test and step-down test, the effect of osthol on learning and memory was observed and the glutathione peroxidase (GSH-PX) activities in blood and superoxide dismutase (SOD) activities in plasma and cerebrum were measured. RESULTS Osthol 15 and 7 5 mg·kg -1 significantly improved the capability of memory and enhanced the activities of GSH-PX and SOD in AlCl 3 treated mice. CONCLUSION Osthol shows protective effect on brain memory impairment of mice in acute senile model induced by AlCl 3. Perhaps the mechanism is involved in enhancing the activities of GSH-PX and SOD, clearing away the free radical, protecting the brain neuron from the harm of lipoperoxide.