维生素B_6伍用二巯基丙磺酸钠治疗四亚甲基二砜四胺急性中毒的实验研究

Antidotal effects of vitamin B_6 and sodium dimercaptopropane sulfonate on acute poisoning with tetramethylene disulphotetramine in animals

目的 研究维生素B6(VitB6)和二巯基丙磺酸钠 (Na DMPS)对四亚甲基二砜四胺 (毒鼠强 )急性中毒动物的解毒作用。方法 通过小鼠急性毒性实验观察染毒即刻及染毒后 10min给予VitB6联合Na DMPS的解毒作用。结果 中毒早期使用VitB6联合Na DMPS能有效抑制急性中毒动物的强直性惊厥 ,明显降低病死率 ,与中毒对照组比较均具有十分显著的意义 (P <0 0 0 1) ;延迟 10min给予同等剂量的VitB6联合Na DMPS治疗 ,不能延长毒鼠强中毒小鼠的惊厥潜伏期 ,但可延长死亡时间 (6 8 8± 15 2 )min ,降低中毒小鼠病死率 (6 0 % ) ,与对照组死亡时间 (31 6± 7 8)min和病死率(10 0 % )比较也有显著意义 (P <0 0 1)。结论 VitB6联合Na DMPS对毒鼠强急性中毒动物有非常明显的解毒作用 ,有望成为临床救治毒鼠强急性中毒的优良解毒剂。

Objective The study was designed to examine the antidotal effects of vitamin B 6 (Vit B 6) with sodium dimercaptopropane sulfonate (Na DMPS) on acute poisoning with tetramethylene disulphotetramine(TETS) in animals Methods Through the acute toxicity experiments, the antidotal effects of Vit B 6 with Na DMPS on mice immediately and 10 minutes after poisoning were observed Results Used of Vit B 6 with Na DMPS in early stage showed excellent inhibition of tetanic convulsion in acute poisoning with TETS in mice and can reduce very significantly the death rate( P < 0 001). Vit B 6 with Na DMPS used 10 minutes after poisoning also significantly elongate the death time(68 8±15 2) and reduce significantly the death rate(60%)then control group′s death time(31 6±7 8) and the death rate(100%)on acute poisoning in mice( P < 0 01) Conclusion Antidotal effects of Vit B 6 with Na DMPS were significant on acute TETS poisoning in animals Vit B 6 with Na DMPS is an excellent antidote for acute TETS poisoning It is suggested that Vit B 6 with Na DMPS may be clinically used to rescue patients poisoned by TETS