血液灌流治疗重度急性有机磷农药中毒的临床研究

Clinical study of severe acute organophosphorus pesticide poisoning treated with Hemoperfusion

目的 :探讨血液灌流 (HP)对重度急性有机磷农药中毒 (AOPP)的临床疗效。方法 :4 6例重度 AOPP患者随机分为 HP组和非 HP组 ,HP组在综合治疗的基础上予以 HP治疗。通过观察两组的昏迷到清醒时间、呼吸肌麻痹发生率、存活率及平均住院天数 4项指标来判断 HP的临床疗效。结果 :HP组存活率 95 .6 5 % ,显著优于非 HP组 (6 9.5 7% P<0 .0 5 ) ;HP后无一例发生呼吸肌麻痹 ,非HP组均出现呼吸肌麻痹。结论 :HP能有效清除体内有机磷 ,预防呼吸肌麻痹的发生 ,提高存活率 ,HP治疗

Objective:To detect the clinical effective of Hemoperfusion(HP)to severe acute organophosphorus pesticide poisoning(AOPP) Methods:46 patients with severe AOPP were diveded into HP group and non HP group randomly Being maintained on routine treatment,HP group were also treated with HP Through observing the four taryets as time from coma to sanity? incident rate of respiratory muscle paralys survival rate and mean days in hospital to evaluate the dinical efficacy of HP Results:The survival rate of HP group was 95 65%,much higher than that of nonHPgroup 69 57%(P<0 05);non of the HP group oc curs respiratory muscle paralys ,while the group without HP all occur respiratory muscle paralys Conclusion:HP can eliminate the organophosphorus pesticide effectively,guard against respiratory muscle paralys,raise the survival rate The efficacy of AOPP treated with HP is significant