检测原发性肝癌血清促吞噬肽水平的临床意义

Clinical Significance of Serum Tuftsin Level in Patients with Liver Cancer

目的 检测原发性肝癌切除前、后血清促吞噬肽 (tuftsin)水平 ,探讨肝癌患者免疫功能的变化 ,确立其在肿瘤免疫中的地位和作用。方法 用放射免疫分析方法检测 12例原发性肝癌患者术前及术后血清促吞噬肽水平 ,以 2 0例肝硬变患者和 2 0例正常人作对照。结果 受检者血清促吞噬肽水平 :肝癌组术前为 (4 4 9± 10 6)ng/ml,明显低于肝硬变组的 (5 80± 187)ng/ml、正常对照组的 (70 3± 12 8)ng/ml和肝癌组术后的 (5 88± 12 9)ng/ml (P<0 .0 1) ;且肝癌组术后水平亦低于对照组 (P<0 .0 1)。结论 对肝癌患者应最大限度地切除肿瘤 ,以增加机体内血清促吞噬肽的含量 ,有利于激活患者NK细胞。

Objective To probe into the significance of tuftsin in patients with liver cancer. Methods The serum tuftsin level of 12 patients with liver cancer before and after the resection,20 cirrhostic and 20 normal controls were measured by radioimmunoassay (RIA). Results Tuftsin level in preoperative group (449±106) ng/ml was much lower than that in postoperative group (588±129) ng/ml,cirrhotics group (580±187) ng/ml and control group (703±128) ng/ml ( P <0.01). The tuftsin level in postoperative group was also quite lower than that in control group ( P <0.01). Conclusion We should try our best to excise the liver cancer so that a higher tuftsin level might be obtained which can activate NK cell and T cell.