胃癌组织中c-erb B-2和组织蛋白酶D的表达及其与胃癌生物学行为间的关系

The Expression of c-erb B-2 and Cathepsin D in Gastric Carcinoma and Its Correlation to the Biological Behavior of Gastric Carcinoma

目的 观察癌基因c erbB 2及组织蛋白酶D(Cath D)在胃癌中的表达 ,探讨二者的关系及其与胃癌生物学行为之间的关系。方法 采用免疫组化S P法检测了 10 2例胃癌手术切除标本的c erbB 2及Cath D的表达 ,同时观察了网状纤维分布与c erbB 2和Cath D之间的关系 ,并将检测结果与跟踪随访资料进行了综合分析。结果 10 2例胃癌组织中c erbB 2表达阳性率为 3 8.2 4% (3 9/ 10 2 ) ,与胃癌浸润深度 (P<0 .0 5 )及淋巴结转移 (P<0 .0 5 )密切相关 ;Cath D表达阳性率为 81.3 7% (83 / 10 2 ) ,与胃癌浸润深度 (P<0 .0 5 )、生长方式 (P<0 .0 5 )、淋巴结转移 (P<0 .0 5 )及脉管内有无癌栓 (P<0 .0 5 )有关。生存期分析显示 :Cath D和c erbB 2表达阳性患者预后差 ,5年生存率低于表达阴性患者。结论 c erbB 2及Cath D与胃癌的生长、浸润、转移及预后有密切关系 ,可作为判断胃癌生物学行为和预后的重要指标 ,为临床诊断。

Objective To investigate the expression of c erb B 2 and Cathepsin D in gastric carcinoma and its correlation with the biological behavior of gastric carcinoma (GC). Methods The expression was studied by immunohistochemical technique. The expression of c erb B 2 and Cathepsin D were analyzed with their relation to histologic types, depth of invasion, growth pattern, lymph node metastasis and prognosis of gastric carcinoma. Results Thirty nine of the 102 gastric carcinoma specimens (38.24%) were positive for c erb B 2 and correlated with depth of invasion ( P <0.05) and lymph node metastasis ( P <0.05); eighty three of the 102 gastric carcinoma specimens (81.37%) were positive for Cathepsin D and correlated with depth of invasion ( P <0.05), growth pattern ( P <0.05), lymph node metastasis ( P < 0.05) and blood vessels cancer embolus ( P <0.05). Prognosis of patients with gastric carcinoma with positive expression of c erb B 2 or Cathepsin D was poor. The 5 year survival rate was significantly lower in gastric carcinoma patients with positive expression of c erb B 2 or Cathepsin D. Conclusion c erb B 2 and Cathepsin D are highly related to growth, invasion, metastasis and prognosis of gastric carcinoma.