p53及VEGF表达与结、直肠癌血道转移发生的关系

Expression of p53 and Vascular Endothelial Growth Factor and Its Correlation with Hematogenous Metastasis in Colorectal Cancer

目的 研究 p5 3及血管内皮细胞生长因子 (vascularendothelialgrowthfactor ,VEGF)表达与结、直肠癌血道转移发生的关系。方法 应用免疫组织化学ABC法检测 79例结、直肠癌组织中p5 3及VEGF的表达。结果 p5 3和VEGF在结、直肠癌组织中表达阳性率分别为 48.1%和 5 8.2 % ;62 .0 %的病例中 p5 3和VEGF表达一致。p5 3及VEGF表达与结、直肠癌静脉侵犯、血道转移密切相关 (P<0 .0 5 ) ,p5 3及VEGF阳性表达组血道转移发生率为 66.7% ,明显高于 p5 3及VEGF阴性表达组和 p5 3阳性表达、VEGF阴性表达组 (P <0 .0 1) ;p5 3及VEGF阴性表达病例中 ,无同时性或异时性血道转移发生。结论 结合分析 p5 3及VEGF表达状态 ,对预测结。

Objective To study the expression of p53 and vascular endothelial growth factor (VEGF) and its correlation with hematogenous metastasis in colorectal cancer. Methods Avidin biotin complex method was used to study the expression of p53 and VEGF in 79 cases of colorectal cancer.Results The positive rates of p53 and VEGF were 48.1% and 58.2% respectively in 79 cases of colorectal cancer. p53 and VEGF expression were identical in 49 (62.0%) cases. There was significant association between p53 or VEGF expression and venous invasion or hematogenous metastasis ( P <0.05). The incidence of hematogenous metastasis in the p53(+)/VEGF(+) subgroup was 66.7% and was significantly higher than that in the p53(-)/VEGF(-) or p53(+)/VEGF(-) subgroup ( P <0.01). Neither synchronous nor metachronous hematogenous metastasis were found in the p53(-)/VEGF(-) subgroup.Conclusion The combination of p53 and VEGF expression is an important predictor for hematogenous metastasis in patients with colorectal cancer.