精氨酸-天冬氨酸抗涎腺腺样囊性癌实验性肺转移的研究

An antimetastatic study of Arg-Asp (RD) on salivary adenoid cystic carcinoma in vivo

目的 研究精氨酸 天冬氨酸 (Arg Asp ,RD)抗涎腺腺样囊性癌实验性肺转移 (salivaryadenoidcysticcarcinomalungmetastation ,SACC LM)的作用。方法 观察不同剂量、不同时间RD灌胃对SACC LM的影响。结果 30mg/kg和 12 0mg/kgRD灌胃可抑制SACC LM的形成 ;7 5mg/kg、30mg/kg、12 0mg/kgRD灌胃均可延长SACC LM鼠的生存期。结论 RD毒性小 ,可经口给药 ,具有抗SACC LM的作用。

Objective To test the antimetastatic effects of Arg Asp (RD) on salivary adenoid cystic carcinoma (SACC LM) in vivo. Methods RD was administered orally to experimental metastasized nude mice. The pulmonary metastatic foci number and survival were determined to assay the antimetastatic effects of RD. Results 30 mg/kg, 120 mg/kg of RD demonstrated an inhibitory effect on the pulmonary metastatic foci formation. All of the tested dosages (7 5 mg/kg, 30 mg/kg, 120 mg/kg) of RD prolonged the survival. Conclusions Oral administration of RD has a antimetastatic effect on SACC LM. RD is low toxicity.