消炎痛含漱液对牙周炎症的作用

The effects of indomethcin rinse on the periodontal inflammation

目的 观察使用消炎痛含漱液 3个月后临床指标和龈沟液 (gingivalcrevicularfluid ,GCF)量及成分的变化 ,探讨局部应用非甾体类抗炎药对牙周疾病的治疗作用。方法 选择 19例曾接受过牙周治疗的成人牙周炎患者 ,随机、双盲分为消炎痛含漱组和安慰剂含漱组 ,连续用药 3个月。用放射免疫法检测龈沟液前列腺素E2 (gingivalcrevicularfluidprostaglandinsE2 ,GCF PGE2 )水平。结果与对照组相比 ,试验组局部应用消炎痛后 ,出血指数和GCF量明显降低 (P <0 0 5 ) ;附着丧失略有改善 ;GCF PGE2 水平明显降低 (P <0 0 5 ) ;两组菌斑降低值之间差异无显著性。结论 局部应用消炎痛后牙周组织炎症得到改善 ,GCF PGE2 水平降低 ;炎症改善主要与局部组织中PGE2 水平的降低有关。

Objective To observe the clinical results and the changes of gingival crevicular fluid prostaglandins E 2 (GCF PGE 2 )levels three months after indomethcin rinsing. Methods Nineteen periodontal patients who had received periodontal treatment before were chosen and divided into two groups randomly: indomethcin test group and placebo control group. The clinical parameters and gingival crevicular fluid (GCF) samples were obtained respectively at 0, 1, 3 month. The levels of GCF PGE 2 were measured by radioimmunoassay(RIA). Results After 3 months′ rinse treatment, the bleeding index and the amounts of GCF in test group decreased significantly than those of the control group. Attachment level improved in test group as well The levels of GCF PGE 2 significantly decreased in test group, which not changed in control group. The percentage value of plaque reduced considerably in both test group and control group after rinsing, but no significant difference was found between these two groups. Conclusion Gingival inflammation and the levels of GCF PGE 2 are reduced after topical indomethcin administration. The effect is related to the decrease of local PGE 2 levels