莴苣叶鲜汁对体外平滑肌的作用

EFFECT OF LACTUCA SATIVAFOLIAGE JUICE ON IN VITRO SMOOTH MUSCLE

目的 :探索莴苣叶鲜汁 (LSFJ)对体外平滑肌的作用。方法 :制备体外兔胸主动脉环、支气管环和小肠标本 ,记录给药后 3min或 5min后上述平滑肌张力的变化。结果 :在Krebs液中加入 0 .2 4 ,0 .4 5 ,0 .6 5 g/ml的LSFJ液后 3min ,血管平滑肌张力分别降低 13.4 %、 19.6 2 %、2 8.9% ,支气管平滑肌张力分别降低 2 1.0 %、4 0 .2 %、6 6 .4 % ;在Tyrode液中分别加入LSFJ 0 .2 4 ,0 .4 5 ,0 .6 5 g/ml后 5min ,小肠平滑肌标本张力分别增加 6 6 %、71%和 82 %。结论 :LSFJ扩张血管 ,减少血流阻力 ,降低动脉血压 ;舒张气管平滑肌 ,减少气道阻力 ;兴奋小肠平滑肌 ,促进小肠运动。

Objective:To investigate the effects of Lactuca sativa foliage juice (LSFJ ) on in vitro smooth muscle. Method: The in vitro rabbit breast aorta ring, bronchus smooth muscle ring and small intestine smooth muscle samples were prepared. The tension changes of smooth muscle mentioned above were recorded after administration of LSFJ for 3, 5 min. Result: After addition of LSFJ 0.24,0.45,0.65 g/ml to the Krebs solution for 3 min, the tension of blood vessel smooth muscle and bronchus smooth muscle was decreased by 13.4%, 19.6%, 28.9% and 21.0%, 40.2%, 66.4%, respectively; After addition of LSFJ 0.24,0.45,0.65 g/ml to the Tyrode solution for 5 min, the tension of small intestine smooth muscle was increased by 66%, 71% and 82%, respectively. Conclusion: LSFJ can diastole blood vessel smooth muscle, reduce resistance of blood flow, lower arterial pressure; diastole bronchus smooth muscle, reduce airway resistance; stimulate intestine smooth muscle.