转移性肺癌的外科治疗及预后影响因素

Surgical treatment and prognosis of pulmonary metastasis

目的 讨论转移性肺癌的外科治疗以及影响预后的因素。方法 本组经外科治疗的肺转移癌 5 9例 ,同时选取 36例未经手术治疗的患者作对照 ,分别随访预后情况 ,并用逐步回归方法分析影响预后的因素。结果 手术与非手术患者的 1、3、5年生存率分别为 70 % ,39% ,34 %和 2 8% ,8% ,0 % ,无病生存期 (DFI) <1年和≥ 1年患者的 5年生存率分别为 2 1%和 40 %。结论 对于符合手术指征的转移性肺癌患者 ,应尽可能手术治疗 ,且DFI越长 ,术后生存时间越长。

Objective To study the surgical treatment and the prognosis of pulmonary metastasis. Methods 59 patients in the operative group and 36 patients in the control group were included . Their clinical data were collected by follow-up investigation and the prognosis was analyzed by stepwise regression.Results The median survival time was 20.2(operative group) and 10.0 (control group) months. The 1,3 and 5-year survival rates in the two groups were 70%,39%,34%(operative group) and 28%,8%,0%(control group) respectively. The 5-year survival rate of patients with disease-free interval ( DFI)<1year was 21%, while that of patients with DFI≥1 year was 40%.Conclusions Resection of pulmonary metastasis should be considered if indicated. DFI is an important prognostic factor for pulmonary metastasis.