NK/T细胞淋巴瘤

NK/T Cell Lymphoma

目的 了解和认识NK /T细胞淋巴瘤的临床病理和免疫学特点。方法 选用NK细胞特异性抗体CD 5 6、T细胞特异性抗体CD3ε ,对 117例T细胞淋巴瘤进行标记。结果 117例T细胞淋巴瘤中 2 6例CD5 6( +)、CD3ε( +) ,阳性表达率为2 2 .2 % ;2 6例中结外淋巴瘤 16例 ( 61.5 % ) ,其中 15例位于鼻部 ;淋巴结内 10例 ( 38.5 % ) ;2 6例中 18例 ( 69.2 % )表现为细胞的多形性特点 ,12例 ( 46.2 % )有凝固性坏死。结论 NK /T细胞淋巴瘤免疫学特点是CD 5 6与CD3ε共同表达。NK /T细胞淋巴瘤多发生在结外 ,以发生于鼻部者为多 ,少数发生在结内 ,肿瘤细胞的多形性和肿瘤组织的凝固性坏死是主要的病理学特点。

Objective To study the characteristics of NK/T cell lymphomas in clinicopathology and immunophenotype.Method Immunohistochemical(IHC) staining for CD56 and CD3ε,specific for NK and T cell respectively,were performed in 117 cases of T cell lymphomas(TCLs),with S P method.Results 26 of 117 TCLs(22.2%) expressed CD56(+)?CD3ε(+)?16 of the 26 cases(61.5%) were extranodal lymphomas,among them 15 cases were located nasal,10 of the 26 cases(38.5%) were nodal lymphomas.18 of the 26 cases(69.2%) showed pleomorphism of neoplastic cells,12(42.9%) presented with coagulation necrosis.Conclusion 22.2% of TCL were NK/T cell lymphomas,most of them developed in extranodal/nasal site and a few were nodal lymphomas.NK/T cell lymphoma was predominantly characterized by the pleomorphism of neoplastic cells and coagulation necrosis of neoplastic tissues.