血清TPS和CA15-3水平变化与乳腺癌的关系及其临床意义

Clinical Value of Serum TPS and CA15-3 Levels in Breast Cancer

目的 探讨血清组织多肽特异性抗原 (TPS)和癌抗原 15 3(CA 15 3)水平检测对乳腺癌的临床应用价值。方法 采用酶联免疫吸附法 ,分别在治疗前后测定 173例乳腺癌和 69例乳腺良性疾病患者血清TPS和CA 15 3水平。结果 乳腺癌组患者TPS和CA 15 3水平及检测阳性率均明显高于乳腺良性疾病和正常对照组 (P <0 .0 1)。CA 15 3水平随临床分期的进展明显升高 ,而TPS即使在临床Ⅰ期也有高水平的表达。乳腺癌患者经有效治疗后其血清TPS和CA 15 3水平均明显降低 ,尤其是单纯根治术或加用放疗的患者降低幅度更为明显。乳腺癌复发患者血清TPS和CA 15 3均明显升高 ,尤其是TPS升高幅度较为显著。结论 TPS和CA15 3联合检测可明显提高乳腺癌的阳性检出率 ,对乳腺癌早期诊断、病情判断、疗效评估和复发监测等均有重要价值 。

Objective To study the clinical value of serum levels of tissue polypeptide specific antigen(TPS) and CA15 3 in breast cancer.Methods TPS and CA15 3 in serum sample of 173 patients with breast cancer were analysed by ELISA in two weeks before and after treatment of operation and drugs.Results The values of TPS and CA15 3 in serum were higher signifficantly in patients with breast cancer than those in the healthy subjects and breast benign diseases groups( P <0.01).The levels of CA15 3 in serum were significantly increased with TNM staging and TPS with clinical stage.The serum levels of TPS and CA15 3 in the breast cancer patients were markedly decreased in two weeks after operation( P <0.01) and no changed in the patients without operation whose condition was stable and it was significantly increased in the patients with progressive and relapse.Conclusion TPS and CA15 3 can be used as useful tumor markers of breast cancer in early diagnosis,evaluation of therapeutic effect,assessing of the prognosis,and it is highly useful in monitoring recurrences of breast cancer,especially when dynamic detection is performed.