PSA、PSAD测定对前列腺癌诊断的价值

The Value of PSA and PSAD Determination in the Diagnosis of Prostatic Cancer

目的 探讨血清前列腺特异抗原 (PSA )和前列腺特异性抗原密度 (PSAD )作为前列腺癌 (PC )诊断指标的价值。方法 采用放射免疫分析方法测定 5 0例前列腺增生 (BPH )患者和 36例前列腺癌 (PC)患者的血清PSA水平 ,B超测定前列腺体积 ,计算单位体积的PSA值 (PSAD)。结果 PSA界限值定为 4μg/L时 ,其诊断PC敏感度为 94% ,特异度为 36% ,准确度为 60 % ;PSA界限值定为 10 μg/L时 ,敏感度为 89% ,特异度为 62 % ,准确度为 73%。PSAD测定诊断PC敏感度为 89% ,特异度为 90 % ,准确度为 90 %。结论 对于前列腺癌的诊断 。

Objective To evaluate the value of serum prostate specific antigen(PSA) and prostate specific antigen density(PSAD) as an indicator for the differential diagnosis between BPH and PC.Methods Serum samples were obtained from 50 men with untreated BPH and 36 men with untreated prostate cancer.PSA levels of all samples were assayed by radioimmunoassay.Results When the upper normal limit of PSA was set at 4 μg/L, the diagnostic sensitivity was 94%,the specificity 36% and the accuracy 60%,If the upper normal limit of PSA was set at 10 μg/L,the sensitivity,speciticity and the accuracy was 89%,62% and 73%,respectively.The diagnostic sensitivity of PSAD determination was 89%,the specificity 90% and the accuracy 90%.Conclusion PSAD may be more useful as a tumormarker for PC.