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PAMAM树状大分子对烟酸增溶效果的影响 被引量：2

Solubility Enhancement of Nicotinic Acid in PAMAM Dendrimers
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摘要 为研究聚酰胺 胺 (PAMAM)树状大分子对弱酸性亲脂性药物烟酸的增溶作用 ,合成了以乙二胺为核的1 .0～ 6 .0代 (G)PAMAM树状大分子 ,研究了不同 pH值、不同质量浓度的树状大分子对烟酸增溶的影响。结果 :pH值、质量浓度均影响PAMAM树状大分子溶液对烟酸的增溶效果。提示 :增溶的主要原因是由于树状大分子的氨基与烟酸的羧基之间存在静电作用 ,PAMAM树状大分子可作为亲脂性弱酸性药物的增溶剂。 PAMAM dendrimers enhance the solubility of nicotinic acid. PAMAM dendrimers of generation 1 to 6 have been synthesized. The study investigated the effect of pH and concentration of the dendrimers on the solubility enhancement of nicotinic acid. The pH and concentration of the dendrimers influenced the solubility enhancement of nicotinic acid. It suggests that an electrostatic interaction between the carboxyl group of the nicotinic acid and the amine groups of the dendrimers is involved.
作者 叶玲 张锦楠 周玉兰 顾微 刘永利 扈金平 朴东旭
机构地区 首都医科大学化学教研室 中国康复研究中心人体组织工程研究所
出处 《首都医科大学学报》 CAS 2002年第1期17-19,共3页 Journal of Capital Medical University
基金 北京市科技新星计划 ( 95 4812 0 0 0 ) 北京市教委科技发展计划 ( 0 0KJ10 7)资助课题
关键词 PAMAM树状大分子 烟酸 增溶 PAMAM dendrimer nicotinic acid solubility enhancement
分类号 R977.22 [医药卫生—药品]
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共引文献19

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首都医科大学学报
2002年 第1期

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