湿热蕴结胆囊结石模型的复制

Reconstruction of Cholelithiasis Model with the Syndrome of Damp Heat Accumulation

目的 复制符合中医学发病特点的湿热蕴结胆囊结石模型。方法 采用含有不同剂量辛辣、油腻的饲料喂养家兔，对胆囊胆汁粘滞度、结石形成及胆囊粘膜病理情况进行观察。结果 模型４组有２只家兔死亡；造模各组胆汁粘滞度均较空白对照组增加，模型２、３、４组增加更为明显；模型２组仅１只家兔有肉眼可见的结石形成，模型３、４组均有６只家兔有肉眼可见的结石形成，３组均有大量的胆固醇结晶析出；模型各组胆囊粘膜病理变化均以炎症性改变为主。结论 上述观察提示使用模型３组（饲料配方为普通饲料∶胆固醇∶辣椒∶动物脂肪按１００∶０．５∶０．５∶１的比例配制）方法复制模型较好。

Objective To reconstruct cholelithiasis models of damp heat accamulation syndrome in accordance with the pathogenesis t h eory of traditional Chinese medicine. Method Adpoting different dos es of pungent and greasy diet to raise the rabbits, we observed the changes of biliary visco s ity and gallstone formimg.Results Two rabbits died in model gro up 4; and com pared with the control group,the biliary viscosity of every model group incre ased. Gallstone of one rabbit was seen with the naked eye in model group 2, g a llstone of six rabbits were observed in model group 3 and 4,and a lot of chole sterol crystal, were observed in model group 3. Conclusion The se findings sugg est that the method adopted in model group 3 ( formula for diet -- norm al diet : cholesterol: pangent : animal greasy = 100∶0.5∶0.5∶1)may be the bes t.