催产素对大鼠虹膜毛细血管通透性的影响

Change of Iridial Capillary Osmosis in Traumatic Wistar Rats Using Oxytocin

目的探讨催产素治疗前房出血以及预防再次出血的机制。 方法选用 2 8只Wistar大鼠麻醉后用钝器敲击双眼 ,造成前房出血。随机分成二组 ,一组用 1U的催产素每天经腹腔注射 ,另一组为对照组。在 1,3,5 ,7,9,11,13d时 ,二组随机选出 2只大鼠 ,左眼行光镜检查 ,右眼虹膜行毛细血管通透性测定。 结果催产素组的透光度形成一个低值水平 ,对照组形成一个高透光度值水平 ,二者透光度值都随时间推延而下降。光镜下可见催产素组的毛细血管间隙血细胞大量减少 ,管腔中充血减轻 ;对照组无此变化。 结论催产素不仅能治疗前房出血 。

Objective To observe the changes of iridial capillary osmosis and search for the co-relation of oxytocin with traumatic recurrent hyphema. Methods We divided the traumatized eyes of 28 rats into two groups:oxytocin group and no medicine group. On d1, 3, 5, 7, 9, 11, and 13, we randomly selected two rats in each group and took their left eyes for pathological examinations, and measured iris tissues of the right eyes transparency of Evan blue in extract liquid with spectrophotometing. Results Lower level of transmittance was observed in the oxytocin group with presence of a few blood cells in the iris tissue. Conclusion Oxytocin is effective for traumatic hyphema and it can also prevent recurrence of hyphema.