桂枝汤对胃肠运动双向调节作用的实验研究 Ⅴ.对血管活性肠肽含量的影响

Experimental Study of “Guizhi Tang”(Cinnamon Twig Decoction) on Dual-direction

桂枝汤可拮抗新斯的明性胃肠功能亢进大鼠的血液、下丘脑、十二指肠和空肠血管活性肠肽（ＶＩＰ）含量的降低，对胃窦ＶＩＰ含量无影响；也可使阿托品性胃肠运动机能受抑大鼠的ＶＩＰ含量降低，并使之趋向正常；对正常大鼠上述组织和血液中ＶＩＰ含量无明显的影响。提示本方对胃肠运动机能的双向调节机理之一可能是通过调节中枢下丘脑、血液、胃肠局部组织ＶＩＰ含量有关。

? Guizhi Tang(Cinnamon Twig Decoction,GZT,桂枝汤) might increase vasoactive intestinal polypeptide (VIP) content which was cut down by neostigmine in plasma,hypothalamus,duodenum,jejunum.Atropine might increase VIP content in these tissues,and GZT might cut down the increase of the hormone content.In addition,GZT didn't influence VIP content in normal rats.Results indicate that GZT may regulate the function of gastrointestinal motility in dualdirection by means of influencing on gastrointestinal hormone VIP contents in plasma,hypothalamus,duodenum,jejunum.