油茶皂甙对高脂血证大鼠模型高密度脂蛋白胆固醇及其亚组分的影响

Effects of Sasanguasaponin on Blood Lipids and Subgroups of High Density Lipoprotein Cholesterol in Hyper Lipoidemia Rat Models

用高脂血症大鼠模型研究了油茶皂甙的调脂作用。血清高密度脂蛋白胆固醇（ＨＤＬ）及其亚组分３（ＨＤＬ３）用聚乙二醇２００００法分离，血脂用酶法测定。实验结果显示油茶皂甙能明显降低血清总胆固醇（ＴＣｈ）、甘油三酯（ＴＧ）、低密度脂蛋白胆固醇（ＬＤＬ）和ＨＤＬ３，不显著改变ＨＤＬ浓度，轻微升高ＨＤＬ亚组分２（ＨＤＬ２），降低动脉硬化指数（ＡＩ）。在１００ｍｇ／ｋｇ以内时，油茶皂甙降低ＴＣｈ、ＴＧ、ＬＤＬ、ＡＩ，升高ＨＤＬ２／ＨＤＬ３比值存在明显量效关系。５０至１００ｍｇ／ｋｇ时油茶皂甙降脂作用强度相当于氯贝丁酯２５０ｍｇ／ｋｇ。

Effects of sasanguasaponin ig for 14 days on blood lipids were investigated in hyperlipoidemia rat models.Serum high density lipoprotein cholesterol (HDL) and subgroup 3 of HDL(HDL3) were isolated with polyethylene glycol 20000.The experimental results showed that sasang uasaponin markedly reduced serum total cholesterol (TCh),triglycerides(TG),low density lipoprotein cholesterol (LDL),and HDL3,not significantly changed HDL concentration,lightly raised subgroup 2 of HDL(HDL2);significantly increased ratio of HDL2/HDL3 but lowered atheroscleorsis index (AI=(TCh-HDL)/HDL).Saponin (under 100mg/kg) dosedependently reduced the TCh,TG,LDL,AI and increased the HDL2/HDL3 ratio.The efficiency in lowering blood lipids of sasangua saponin (50 to 100mg/kg) corresponds to that of Clofibrate (250mg/kg).Therefore it is regarded that the saponin can regulated serum lipids of hyperlipoidemia animal models to have role in protection from atheroscleosis.