地黄低聚糖对小鼠免疫和造血功能的作用

Effects of Rehmannia glutinosa oligosaccharide on immunological and hematopoietic function in mice

采用免疫学和实验血液学方法，研究和探讨了地黄低聚糖对小鼠免疫功能和造血功能的作用。结果表明：地黄低聚糖４０ｍｇ／ｋｇ可增强正常小鼠的ＰＦＣ反应，而２０、４０ｍｇ／ｋｇ，可提高Ｃｙ抑制小鼠和荷瘤小鼠的ＰＦＣ数及增强荷瘤小鼠的淋巴细胞增殖反应。同时地黄低聚糖１０～４０ｍｇ／ｋｇ可促进骨髓造血祖细胞的增殖与分化。结果提示地黄低聚糖可明显增强免疫抑制小鼠的体液免疫和细胞免疫反应，同时可促进小鼠骨髓造血祖细胞的增殖分化。

? To investigate the effect of Rehmannia glutinosa oligosaccharide(RGOS) on immunological and hematopoietic function,we study the effect of RGOS on antibody forming cells,lymphocyte proliferation and proliferation of hematopoietic progenitor cells.Results indicated that RGOS 40mg/kg could enhance PFC reaction in normal mice,when rehmannia glutinosa oligosaccharide was orally adminstered 20～40mg/kg once day for 7 consecutive days,it could markdly increase the number of PFC in mice suppressed by Cy and tumorbearing,and promote the proliferation of lymphocyte in tumorbearing mice.Meanwhile,RGOS(10～40mg/kg) promoted the proliferation and differentiation of hematopoietic progenitor cells of bone marrow in mice. These results suggested that RGOS could markdly enhance the humoral and cellular immune function in immunosuppressed mice and promote the proliferation and differentiation of hematopoietic progenitor cells of bone marrow in mice.