淫羊藿多糖对老年大鼠神经内分泌免疫调节作用的研究

Studies on neuroendocrinoimmunological regulation of senile rats by using Epimedium Polysaccharides(EPS)

采用自然衰老雄性大鼠，观察给予淫羊藿有效组分－多糖（ＥＰＳ）前后下丘脑和皮质β内啡肤（βＥｎｄ）含量、血促性腺激素（ＬＨ、ＦＳＨ）、睾酮（Ｔ）、雌二醇（Ｅ２）、白细胞介素２（ＩＬ２）、自然杀伤细胞（ＮＫＣ）活性。结果表明，与青年鼠比较，衰老大鼠上述各指标均有不同程度的降低。应用ＥＰＳ后，老年大鼠下丘脑和皮质βＥｎｄ含量和ＩＬ２、ＮＫＣ活性明显提高，提示淫羊藿多糖可明显增强机体免疫功能和神经肽含量。

 The following determinations were carried out in the naturalsenile animals (21month old rat) after the treatment.Hypothalamus and frontal contex β-endorphin,luteinizing hormone,follicle-stimulating hormone,testosterone,estradiol in the blood,rat induction of interleukinⅡ(IL-2) and the activity of natural killer cells(NKC).The senile rat's above indexes decreased obviously(control:young rats),and by using EPS,βendorphin,rat induction of interleukinⅡ(IL-2)and the activity of natural killer cells(NKC).The senile rat's above indexes decreased obviously(control:young rats),and by using EPS,β-endorphin,rat induction of interleukinⅡ(IL-2) and the activity of natural killer cells(NKC) were improved respectively. The results suggested that EPS could improve senile body's regulation of neuroimmunologic effect and delay senility.