摘要
千金藤素(Ceph)浓度依赖性地抑制酵母多糖和A23187诱导的大鼠中性白细胞内Ca2+浓度增加及活性氧生成;Ceph也抑制花生四烯酸(AA)、胶原及ADP诱导的兔血小板聚集。和吲哚美辛比较,Ceph抑制活性氧生成的作用较强而抑制血小板聚集的作用较弱。
Cepharanthine (Ceph) was demonstrated to alleviate the production of active oxygen species and the enhance intracellular calcium concentration on rat neutrophils stimulated by zymosan or A 23187 , and inhibit the rabbit platelet, aggregation induced by ADP, Collagen or arachidonic acid. As compared to indomethacin, Ceph was shown to be more potent against the generation of active oxygen species from rat neutrophils, and weaker against platelet aggregation.
出处
《中药药理与临床》
CAS
CSCD
1997年第3期12-14,共3页
Pharmacology and Clinics of Chinese Materia Medica