活血化瘀方对大鼠急性胃粘膜损伤的保护作用及机理研究

Protective effect of blood-activating drugs on acute gastric mucosal injury

本实验观察了活血化瘀药物（丹参、赤芍、川芎、莪术组成）水提液对盐酸乙醇致急性胃粘膜损伤的保护作用，结果显示活血化瘀方５．４ｇ／ｋｇ、１０．８ｇ／ｋｇ、２１．６ｇ／ｋｇ对损伤模型具有很好的保护作用，并呈明显的量效关系；预先灌胃１０．８ｇ／ｋｇ能显著抑制盐酸乙醇引起的大鼠血浆过氧化脂质含量升高，对红细胞超氧化物歧化酶活性降低有抑制趋势。

Rat animal model of acute gastric mucosal injury was induced by enthanol-HCl to study the protective effect of blood-activating drugs (BAD) on acute gastric mucosal injury.Blood- activating decoction was given prior to enthanol-HCl. The results indicate that pretreatment with BAD can significantly atlenuate the gastric mucosal injury and the protective effect has relation with dose, it also can reduce LPO content and increase SOD activity. It is suggested that the BAD has protective effect on gastric mucosal injury,it might be due to improvment of gastric mucosal defence mechanism and scavenging function of oxygen free radicals.