灵芝对D-半乳糖亚急性损伤的预防作用

The Preventive Effects of Ling Zhi on the Sub acute Injury Induced by D Galactose

在Ｄ半乳糖所致小鼠亚急性损伤引起衰老的模型上，以脑内ＭＡＯＢ活性和尾腱中羟脯氨酸（Ｈｙｐ）含量为指标，检测了灵芝的作用。结果Ｄ半乳糖可明显提高实验小鼠ＭＡＯＢ的活性和Ｈｙｐ含量，而２５０ｍｇ／ｋｇ和５００ｍｇ／ｋｇ的灵芝可有效的抑制Ｄ半乳糖的作用，降低ＭＡＯＢ的活性和Ｈｙｐ含量。

This study was to investigate the effects of Ling Zhi (LZ) on the animal aging model of sub acute injury induced by D galactose(D G),i.e. the mice were given sc with 40mg D G/kg·d,causing sub acute injury.The activity of monoamine oxidase B(MAO B) in mice's brain and the contents of hydroxyproline (Hyp) in mice's tail were detected as the observing parameters.The sc injection of D G obviously resulted in the increase of the MAO B activity and the Hyp contents in the experimental animals,leading to a sub acute injury.LZ in 250 and 500mg/kg effectively inhibited the actions of D G,decreasing the MAO B activity and Hyp contents.The inhibition showed a dose dependent manner.This study has proved that LZ can antagonize the sub acute injury induced by D G,showing its anti aging action in some extent.