雷公藤多甙对胸腺T细胞免疫功能的动态研究

Dynamical Observation of Tripterygium Wilfordii Hook on the T cell Immunological Effects in Thymus of Rats

本文报告雷公藤多甙（ＧＴＷ） 对大鼠胸腺免疫功能的影响。结果显示，给药后ＧＴＷ 对由ＣｏｎＡ诱导的胸腺Ｔ 细胞的ＤＮＡ 合成能力及ＩＬ２ 的产生和活性、Ｔ 细胞对ＩＬ２ 的反应性等均在１２ ～２４ｈ 时有显著抑制作用，３ 天后抑制作用下降，７ 天后作用基达本消失，认为ＧＴＷ 可以通过改变Ｂ／Ｔ，ＴＨ／ＴＳ

The influence of Tripterygium wilfordii Hook (GTW) on the immunological function in rat's thymus was studied. The results showed that the synthetic ability of DNA in T cell of thymus induced by ConA, the IL 2 production activity and the proliferation response of IL 2 were inhibited markedly in 12 to 24 hours after given ig. The inhibited effect was weaker after 3 days and the effect was restorative after 7 days. It is suggested that the mechamism of immunological regulation effect of the GTW were change the proportion of B/T and T H/T S relatively.