醒脑静注射液对急性大灶性脑梗塞患者血清肿瘤坏死因子、可溶性血管细胞粘附分子-1的影响

Effect on Serum Tumor Necrosis actor and Soluble Vascular Cell Adhesion Molecule 1 of Xing Nao Jing Injection(醒脑静注射液) in Treating Acute Large Cerebral Infarction Cases

目的：探讨醒脑静注射液对急性大灶性脑梗塞患者炎症反应的影响。方法：４２ 例患者随机分为２组：对照组２１ 例（ 常规方法治疗） ，醒脑静组２１ 例（ 常规加醒脑静注射液治疗） ，观察治疗前后血清肿瘤坏死因子（ＴＮＦ） 、可溶性血管细胞粘附分子－ １（ＳＶＣＡＭ－ １） 的变化与临床疗效，并与１９ 名健康人对照。结果：两组患者治疗前血清ＴＮＦ、ＳＶＣＡＭ－ １ 均显著高于健康组，治疗后显著改善，而且以醒脑静组改善更为明显；醒脑静组治愈、显效率也显著高于对照组（５７－１ ％ 与３３－３ ％ ，Ｐ＜ ０ ．０５） 。

Objective: To explore the effect of inflammation of Xing Nan Jing Injection (XNJI) in treating acute large cerebral infarction disease.Methods: 42 cases of acute large cerebral infarction disease were randomly divided into two groups:control group (n=21, treated with normal methods) and XNJI group (n=21, treated with normal medicine and XNJI). The serum levels of tumor necrosis factor (TNF) and soluble vascular cell adhesion molecule 1 (SVCAM 1) before and after treatment and clinical efficacy were observed.Results: The levels of TNF and SVCAM 1 before treatment were very higher than the healthy group (P<0.001), and after treatment they were improved signifficantly (P<0.001), the improvment of TNF and SVCAM 1 in XNJI group was obviouser than that in control group (P<0.01). The marked offective and curative rate of XNJI group was higher than that of control group (57.1% and 33.3%, X 2=4.84, P<0.05).Conclusion: The ability of proventing the inflammation of cerebral infarction may be the important mechanism for XNJI to treat this disease.