雌、孕激素受体和C-erbB-2在原发胆囊癌中的表达及意义

Expression of Estrogen Receptor,Progesterone Receptor and C?erbB?2 Oncogene in Gallbladder Cancer and Their Clinical Significances

目的 探讨雌、孕激素受体 (ER、PgR)和C erbB 2癌基因蛋白产物在原发胆囊癌发生、发展中的作用及相互关系 ,研究它们的表达与肿瘤的病理类型、分级 ,临床分期及预后的关系 ,并为该病的临床诊治提供参考依据。方法 应用免疫组织化学法 ,检测 3 5例原发胆囊癌 ,2 0例慢性胆囊炎组织中ER、PgR和C erbB 2癌基因蛋白的表达水平。结果 在原发胆囊癌中ER、PgR和C erbB 2阳性表达率分别为 60 %、4 5 .7%和 65 .7%。ER的阳性表达与浸润及淋巴结转移密切相关 (P <0 .0 5 )。C erbB 2过度表达与胆囊癌淋巴结转移有关 (P <0 .0 5 )。ER或PgR阳性患者的累计生存率明显低于阴性者。结论 ER、PgR及C erbB 2在原发胆囊癌中的表达率显著高于其在胆囊良性病变中的表达率。ER或PgR阳性者积累生存率显著低于ER或PgR阴性者。

Purpose: To investigate the role of expression of estrogen receptor(ER), progesterone receptor (PgR) and C-erbB-2 oncogene in the development of gallbladder cancer, as well as the relationship of their expression with histological type pathological grading and prognosis in gallbladder cancer. Methods: ER, PgR and C-erbB-2 were assessed in 35 cases of gallbladder cancer and 20 cases of chronic cholicystitis by immunohistochemical assay. Results: The positive rate of ER, PgR and C-erbB-2 was 60%, 45.7% and 65.7% respectively, which was in gallbladder cancer significantly higher than that in non-malignant gallbladder tissues (P < 0.01). The expression rate of ER was positively correlated to the cell-differentiation and metastasis of gallbladder cancer (P < 0.05). The ER or PgR negative patients have a longer survival time than the ER or PgR positive one. Conclutions: The positive rate of ER, PgR and C-erbB-2 was detected significantly higher in gallbladder cancer than that in nonmalignant gallbladder tissues. The survival rate in ER or PgR positive patients is lower than that in ER or PgR negative patients. ER might be an important biological marker to evaluate the malignancy and prognosis of gallbladder cancer.