不同性别血管紧张素转化酶基因型与原发性高血压相关性研究

Sex difference of the association of angiotensin converting enzyme gene locus with hypertension and blood pressure

目的 :探讨男、女不同性别的血管紧张素转化酶 (ACE)基因型与原发性高血压 (EH)的相关关系。方法 :应用聚合酶链反应 (PCR)技术检测 12 8例男性 (其中EH患者 73例 ) ,79例女性(其中EH患者 4 3例 )ACE基因插入 /缺失 (I/D)多态性。结果 :男性组EH患者DD基因型频率(0 .35 6 )和D等位基因频率 (0 .5 75 )显著高于对照者 (0 .182和 0 .4 2 7,分别P <0 .0 5 ,<0 .0 2 )。且ACEDD基因型与男性EH患者的收缩压和脉压增高有关 (P <0 .0 5 )。而女性ACE基因型与EH及血压无显著相关性存在 (均P >0 .0 5 )。结论 :ACE基因I/D多态性对男性EH的发生及血压的增高有显著影响 ,而对女性无此作用。

Objective:To study the association of angiotensin-converting enzyme (ACE) gene insertio-deletion (I/D) polymorphism with systemic hypertension and with blood pressure in men and women respectively.Method:ACE gD/I polymorphism identified by polymerase chain reaction (PCR) was performed in 128 men (73 hypertensives among them)and 79 women (43 hypertensives among them). Result:In male groups, the frequencies of DD genotype ( 0.356) and deletion allele( 0.575)among hypertensives were higher than those among controls ( 0.182 and 0.427) (P< 0.05 and P< 0.02, respectively). But no significant differences could be detected between the polymorphism of ACE gene and hypertension in women (P> 0.05). Furthermore, there was an association of the ACE DD genotype with increased systolic blood pressure (SBP) and pulse pressure (PP) in male hypertensives (P< 0.05), but not in female hypertensives (P> 0.05).Conclusion: There is evidence for association of ACE locus with hypertension and with SBP and PP in men but not in women.