Mu、Kappa受体激动剂、拮抗剂对大鼠肠道传输功能的影响

EFFECT OF AGONISTS, ANTAGONISTS OF MU, KAPPA RECEPTORS IN MOUSE INTESTINE TRANSMISSION FUNCTION

目的 :观察 Mu、 Kappa阿片受体激动剂、拮抗剂对大鼠肠道传输功能的影响。方法 :采用大鼠泻剂结肠模型 ,采用活性炭悬液推进法测定肠道传输功能。结果 :“泻剂结肠”组的肠道炭沫推进距离较对照组显著缩短 (P <0 .0 5 )。不同剂量的 Mu阿片受体激动剂均使肠道炭沫推进距离非常显著的短于对照组 (P <0 .0 1)。随 Mu阿片受体拮抗剂剂量的增加 ,测定的炭沫推进距离显著长于对照组 (P <0 .0 5 ,P <0 .0 1)。 kappa阿片受体激动剂和拮抗剂对“泻剂结肠”大鼠肠道传输功能无明显的作用。结论 :阿片受体激动剂和拮抗剂参与了对“泻剂结肠”肠道传输功能的影响 ,主要是通过 Mu阿片受体 ,Kappa阿片受体无明显的作用。

Objective: To observe the effect of agonists, antagonists of Mu, Kappa receptors in mouse intestine transmission function. Methods: Set up mouse model of cathartic colon, and measure intestine transmission function by detecting activated charcoal moving in the intestine. Results: The charcoal in cathartic colon group moved for a significantly shorter distance than that in control group (P<0.05). Different doses of Mu receptor agonist made charcoal in intestine move a very significantly shorter distance than that in control group (P<0.01). With increasing doses of Mu receptor antagonist, the distance was significantly longer than that in control group (P<0.05,P<0.01). Agonist, antagonist of Kappa receptor had no effect on intestine transmission function in cathartic colon mouse. Conclusion: Agonists, antagonists of opium receptor had effect intestine transmission function in cathartic colon mouse, mainly by Mu receptor, little by Kappa receptor.