有遗传史的原发性高血压患者子代血浆内皮素和一氧化氮浓度的比较性研究

Significance of plasma endothelin and nitric oxide concentration in the hypertensives and their descendants

目的 :探讨内皮素 1(ET 1)与一氧化氮 (NO)在有遗传史的原发性高血压 (EH)子代中的作用及临床意义。方法 :用ELISA方法检测有EH遗传史的患者及其子代和正常人群者及其子代血浆ET 1和NO水平 ,并将两者进行比较。结果 :①EH患者比正常人群者血浆ET 1水平明显升高 (P <0 .0 1) ,血浆NO水平也明显高于后者 (P <0 .0 1)。②有EH遗传史的血压正常的子代与正常人群的子代相比 ,血浆ET 1水平差异无显著性意义 (P >0 .0 5 ) ,而前者NO水平明显高于后者 ,差异有非常显著性意义 (P <0 .0 1)。结论 :①EH患者血浆ET 1水平明显升高 ,而在他们血压正常的子代中不增高。提示 :EH可引起机体内血浆ET 1水平增高 ,从而参与或促进EH的发展 ;但这种高ET 1水平 ,可能并无遗传性。②有EH家族史血压正常的子代中 ,血浆NO水平增高 ,提示在这些人的机体内 ,可能存在NO抵抗作用。

Objective:To investigate the effect and the clinical significance of endothelin-I (ET-1) and nitric oxide (NO) in the pathogenesis of hypertension. Method:The concentrations of plasma ET-1 and NO were detected by ELISA in patients with hypertension and their descendants and in healthy people and their descendants. Then, the above paramenters were compared between different groups. Result:① Both plasma ET-1 and NO level were elevated significantly in hypertensives compared with healthy people. ②There was no significant difference between the plasma ET-1 level in the healthy descendants of hypertension and that in normal people, but the NO level was significantly higher in the former than in the latter (P< 0.01). Conclusion:Plasma ET-1 level elevates in the hypertension but not in their descendants with normal blood pressure. It indicates that ET-1 is not related to pathogenesis of hypertension. The plasma NO level elevates in descendants with hypertensive genetic history but with normal blood pressure, indicating the possible existence of resistant action of NO.