食管癌p27基因表达及其临床意义

Expression and clinical significance of p27 in esophageal carcinoma

目的 :研究食管癌中p2 7基因表达及其临床意义。方法 :用免疫组化SP plus方法检测 32例正常食管组织和 88例食管鳞癌中 p2 7基因的表达。 结果 :食管鳞癌中P2 7蛋白表达阳性率为 40 9%,而正常组织中为75 0 %。P2 7蛋白表达与肿瘤组织分化、有无区域淋巴结转移相关 ,而与肿瘤长度、浸润深度、TNM分期不相关。P2 7蛋白阴性提示预后较差。结论 :从蛋白水平证明p2 7基因表达缺失或表达水平的降低与食管癌的发生有关 ,P2 7蛋白表达的检测可能成为判断食管癌预后的参考指标之一。

Purpose:To study the expression and clinical significance of p27 in esophageal carcinoma. Methods:Immunohistochemical staining was used to determine the expression of p27 in 32 cases of normal esophageal issues and 88 cases of esophageal carcinoma.Results:The positive incidences of P27 expression in esophageal carcinoma was 40.9% while in normal esophageal issues it was 75.0%. The expression of p27 was correlated to degree of differentiation of carcinoma and lymph node metastasis, but not to length, depth of invasion and TNM stage. The p27 negative group was seen to have the worst survival rate among all groups.Conclusions:The results suggest that p27 gene plays an important role in carcinogenesis and progress of esophageal carcinoma. Expression of P27 may prove to be valuable in prognosis assessment of esophageal carcinoma.