基质金属蛋白酶在胃肠癌中的表达及其抑制剂的研究进展

Advances in research on the expression of matrix metalloproteinases in gastrointestinal cancer and their inhibitors in treatment

基质金属蛋白酶 (MMP)是一大类锌依赖性内肽酶家族 ,均能降解一种或几种细胞外基质 (ECM )成分。其活性受到特异性金属蛋白酶抑制剂 (TIMP)的抑制。MMP通过降解细胞外基质及基底膜在胃肠癌的浸润与转移中起重要作用。针对抑制MMP的治疗方法展开了深入的研究 ,合成的MMP抑制剂在肿瘤的浸润与转移的治疗中将有广阔的前景。

Matrix metalloproteinase (MMP) are a family of zinc-dependent endoproteinases whose enzymatic activity is directed against components of the extracelluar matrix(ECM). Their activities are inhibited by the tissue inhibitor of metalloproteinase (TIMP). MMP exerted an important role in invasion and metastasis of gastrointestinal cancer through degrading the ECM. With further research on inhibition of MMP, synthetic MMP inhibitor will have good prospects in the treatment of tumor invasion and metastasis.