双氯芬酸钠栓对髋关节术后疼痛的影响

The Analgesic Effect of Diclofenac Sodium Suppository Following Hip Joint Surgery

目的 :观察双氯芬酸钠栓直肠给药对髋关节手术后疼痛的疗效。方法 :12 0例患者随机分成三组 ,治疗组(A组、B组 )术毕、术后 12 ,2 4h分别各 1次 5 0 ,10 0mg双氯芬酸钠栓置入直肠内。对照组术后常规肌肉注射哌替啶镇痛。结果 :治疗组与对照组使用不同镇痛方法后 ,治疗组 6 ,12 ,2 4,36h的VAS评分均小于对照组 (P <0 .0 1) ,且术后不同时段镇痛的优良率明显高于对照组 (P <0 .0 5或P <0 .0 1) ,2 4h内睡眠时间比较治疗组明显好于对照组 (P <0 .0 5或P <0 .0 1)。恶心、呕吐等严重胃肠道不良反应比较差异无显著性 (P >0 .0 5 ) ,治疗组出汗或大汗淋漓反应明显多于对照组 (P <0 .0 5 )。结论 :双氯芬酸钠栓直肠给药可作为髋关节术后一种简单方便。

Objective:To evaluate the analgesic effect of rectally administered diclofenac sodium suppository after hip joint surgery. Methods:120 patients were randomly divided into 3 groups. Patients of group A and group B (the treatment groups) were given each 50 and 100 mg, respectively, of diclofenac sodium suppositories administered rectally at the time just after surgery, and 12 as well as 24 hours postoperatively. Patcents of group C (the control group) received routine intramuscular injections of pethidine for analgesia. Results:The VAS scores of the patients in the two treatment groups 6, 12, 24 and 36 h postoperatively were smaller than in the control group (P<0.01). The analgesic efficiency in the two treatment groups at different postoperative time belts was markedly higher than in the control group (P<0.05 or P<0.01). Duration of sleep in the treatment groups within 24 hours after the surgery was apparently longer than in the control group (P<0.05 or P<0.01). Postoperative nausea and vomiting were not common in patients of all the three groups. Perspiration or profuse sweating were much commoner in patients of the treatment groups than in those of the control group (P<0.05). Conclusion: Rectal administration of diclofenac sodium suppository is a simple and effective means for postoperative analgesia bollowing hip joint surgery.