鼻咽癌P^(16)基因的异常表达及其临床意义的探讨

Abnormal expression and clinical significance of nasopharyngeal carcinomas gene P^(16)

目的 :研究鼻咽癌抑癌基因P16存在的状态及其与鼻咽癌发生、发展的关系。方法 :采用免疫组织化学S P法对 6 0例鼻咽癌、38例鼻咽癌旁组织和 2 0例正常或炎性鼻咽组织P16基因的表达进行检测。结果 :鼻咽癌、癌旁、正常或炎性组织中P16基因总阳性率为 2 3 33%、73 6 8%和 80 0 0 % ,前者与后两者阳性之间比较均有显著性差异 (P <0 0 5 ,r=- 0 5 114 ) ,而后两者阳性率比较无显著性差异 (P >0 0 5 )。在 6 0例鼻咽癌中 ,有淋巴结转移 4 4例 ,P16基因阳性率 18 88% ,无淋巴结转移 16例 ,P16基因阳性率 5 0 0 0 % ,两者阳性率比较有显著性差异 (P <0 0 5 ,r =- 0 376 4 )。结论 :P16基因低表达或缺失与鼻咽癌的发生。

Objective:To study expression of the cancerinibited gene P 16 in nasopharyngeal darcinomas,and its relation with the occuring and developing of nasopharyngeal carcinoma.Methods:expression of P 16 genes in 60 cases NPC tissues(A group),38 cases NPC paratissues(B group) and 20 cases normal or inflammational nasopharyngeal tissues(C group) were studied by immunohistochemical SP method.Results:The total positive rate in A group,B group and C group were 80 00%,73 68%,23 33%,respeatively.There were significant difference between the A group and B?C groups(P<0 05),and no sifnificant difference between B group and C group.Conclusion:The low expression or deficiency of P 16 gene is connected with occuring and developing of NPC.